Technology
Combining the power of multiple antibodies
in ONE MOLECULE
At Hinge Bio, we are redefining what antibody therapeutics can achieve. Our proprietary GEM-DIMER™ platform combines the power of multiple antibodies into one molecule, enabling multidimensional target and effector engagement with an unmatched combination of avidity, specificity, and geometry.
The result is antibody candidates with superior biological activity and the potential to fundamentally change outcomes for patients with complex, serious diseases.
THE GEM-DIMER™ PLATFORM
A revolutionary class of ANTIBODY THERAPEUTICS
The GEM-DIMER™ platform enables us to design and manufacture antibodies that can:
(a) bind disease targets in a multivalent, mono- or multispecific, and multidimensional manner, using best-in-class binding domains to address clinical challenges such as drug resistance and suboptimal response, and
(b) uniquely possess two Fc domains, allowing for unprecedented advances such as enhanced, multivalent binding to immune effector cells driving greater activity than conventional approaches.
Hinge Bio’s GEM-DIMER™ platform enables modular design, efficient manufacturing, and precise targeting for a variety of target product profiles and has demonstrated encouraging preclinical efficacy and safety across multiple therapeutic programs.